Seroxat and birth defects

In another great article, Evelyn Pringle writes about Paxil Birth Defect Litigation – Battle of the Decade.

Just over a year ago, the FDA reclassified Paxil (Seroxat) from a Category C drug to a Category D for pregnant women. Category C is for drugs that have been shown to harm the fetus in animals. Category D means a drug has been found to harm the human fetus.

In a December 1, 2006 news release, the American College of Obstetricians and Gynecologists’ Committee on Obstetric Practice, advised that Paxil should be avoided “by pregnant women or women planning to become pregnant due to the potential risk of fetal heart defects, newborn persistent pulmonary hypertension, and other negative effects.”

An interesting comment in the announcement states: “Unpublished data regarding the use of Paxil during the first trimester of pregnancy have raised concerns about an increased risk of congenital heart malformations.”

This discussion begs the question of exactly how much more “unpublished data” is out there about the dangers of Paxil that the public will hear about later, rather than sooner.

Please go and read Evelyn’s great (as ever) article – the link is at the top of this post.

Thanks also to Mouse at Paxil Progress and Truthman30 for reminding me about this horrible aspect of Seroxat.

One Response to “Seroxat and birth defects”

  1. Jack Says:

    FDA Paxil Alert
    “FDA Alerts and Related Information
    Persistent Pulmonary Hypertension (7/2006)
    The results of a study that looked at the use of antidepressant medicines during pregnancy in mothers of babies born with a serious condition called persistent pulmonary hypertension of the newborn (PPHN) were recently published in a medical journal.

    Babies born with PPHN have abnormal blood flow through the heart and lungs and do not get enough oxygen to their bodies. Babies with PPHN can be very sick and may die.

    The study results showed that:

    * babies born to mothers who took selective serotonin reuptake inhibitors (SSRIs), the family of medicines Paxil belongs to,
    * 20 weeks or later in their pregnancies,
    * had a higher chance (were 6 times as likely) to have persistent pulmonary hypertension (PPHN),
    * than babies born to mothers who did not take antidepressants during pregnancy.”


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