Wellbutrin XL slightly better than sugar pill – it’s official

Wellbutrin is an antidepressant – a multiple reuptake inhibitor – it is used to treat depression and to stop smoking (as Zyban).

Off label however, it’s also used for weight loss, bipolar depression, ADD/ADHD, fibromyalgia, arthritis, chronic fatigue, multiple sclerosis, lupus, headaches, irritable bowel syndrome (IBS)… and since June 2006, SAD.

Please read on… (from the Mayo Clinic):

“People who have seasonal affective disorder (SAD) and experience depression during waning daylight hours may find relief in a medication approved to prevent this potentially debilitating condition.

The Food and Drug Administration (FDA) has approved the antidepressant bupropion hydrochloride extended release (Wellbutrin XL) for prevention of depression in people with seasonal affective disorder (SAD).

With the approval, Wellbutrin XL becomes the first medication approved to prevent SAD, a type of depression characterized by seasonal episodes of depressed mood, loss of energy, social withdrawal, increased sleep and other, sometimes debilitating, symptoms. Wellbutrin XL is already FDA approved to treat depression.

The FDA noted that Wellbutrin XL’s effectiveness for preventing SAD episodes was demonstrated in three clinical trials. In the trials, approximately 1,000 people with seasonal affective disorder were randomly chosen to receive either Wellbutrin XL or a placebo beginning in the fall and winter, before the onset of symptoms of depression. Treatment was stopped in the spring.

Pooled results of the three studies showed that 84 percent of people taking Wellbutrin XL were free of depression, compared with 72 percent taking the placebo. All of the studies were funded by Wellbutrin XL’s manufacturer, GlaxoSmithKline.

As with other antidepressants, Wellbutrin XL poses potential side effects and health risks. Certain antidepressants, including Wellbutrin XL, may be associated with worsening symptoms of depression or suicidal thoughts or behavior”.

Point 1 – how good is that placebo sugar pill! It cured 72% of people in the trials (with no side effects).

Point 2 – why bother with Wellbutrin at all when the sugar pill is so good – and GSK tells us that if we take its drug, we’d better watch out, because “Wellbutrin XL poses potential side effects and health risks. Certain antidepressants, including Wellbutrin XL, may be associated with worsening symptoms of depression or suicidal thoughts or behavior”. [Not to mention there is a risk of seizure with Wellbutrin XL]

Point 3 – Find out about other Wellbutrin side effects here.

The FDA – doing a great job as ever.


3 Responses to “Wellbutrin XL slightly better than sugar pill – it’s official”

  1. Matthew Holford Says:

    Too funny! Has anybody patented the word “Placebo”, or the chemical formula for glucose, yet? I think we may have stumbled onto a cunning ruse for making our millions!

    The thing is, what makes the placebo work? How can people think themselves better, because that’s what they do, we’re told. It follows, then, that if I were to convince any person reading this, that just by talking to me, on any subject, that they would be cured of their depression, then that’s exactly what would happen. The power of suggestion.

    By the same token, it follows that any GSK stoolie reading this will turn puce, before sending in their report!


  2. truthman30 Says:

    The Placebo effect has long been a matter of debabte..
    But it is remarkable how in most trials for Seroxat and other drugs the placebo did out-perform the drugs …
    But it’s not in their interest to educate the public on this..
    Nor is it in their interst to educate the public on alternatives to medication, such as healthy diet and exercise, which have also proven to be safer and more effective ways of dealing with life’s challenges and stresses…
    It is in their interest though to disable and disempower the public with their mind bending drugs…
    It is a form of coercion and control…
    It is coercion and compliance in the shape of a toxic pill…

  3. Cheshire Agusta Says:

    So if you’re trying to prevent pregnancy and you want to have regular sex, which do you choose, a contraceptive that works 72% of the time or a contraceptive that works 84% of the time? No no no! You only have two choices. Can’t use the foam AND the condom or the rhythm method AND the cervical cap….tut tut tut.
    No one treatment for depression works for all humans. No doctor recommends a pill all by itself to treat depression. Medications are prescribed along with talk and cognitive therapy and at times along with other somatic therapies.
    Untreated depression can also lead to increased feelings of hopelessness and suicide. If you can treat your depression with a sugar pill; go for it, but don’t throw the other however many percent of us down the toilet while you’re at it.

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