Antidepressants: Hiding and Spinning Negative Data

More on my previous post – Antidepressants don’t work as well as reported – negative trials simply not published.

What follows are selected details from Clinical Psychology and Psychiatry – but you really need to go over and read the whole article.

“The FDA concluded that 38 studies yielded positive results. 37 of these 38 studies were published. The FDA found mixed or “questionable” results in 12 studies. Of these 12 studies, six were not published, and six others were published as if they were positive findings. Of the 24 studies that the FDA concluded were negative, three were published accurately, five were published as if they were positive findings, and 16 were not published.

Every single drug had an inflated effect size in the medical literature in comparison with the data held by the FDA. To move into layman’s terms for a moment, manufacturers of every single drug appear to have cheated. This is not some pie in the sky statistics review — this is the medical literature (the foundation of “evidence-based medicine”) being much more optimistic about the effects of antidepressants than is accurate. This is marketing trumping science.

The drugs that were found to have increased their effects as a result of selective publication and/or data manipulation:
Bupropion (Wellbutrin)
Citalopram (Celexa)
Duloxetine (Cymbalta)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Mirtazapine (Remeron)
Nefazodone (Serzone)
Paroxetine (Paxil)
Sertraline (Zoloft)
Venlafaxine (Effexor)
That is every single drug approved by the FDA for depression between 1987 and 2004.”

As I said – read the entire article at Clinical Psychology and Psychiatry – here.

Also Furious Seasons has written about this – here.

2 Responses to “Antidepressants: Hiding and Spinning Negative Data”

  1. Matthew Holford Says:

    The extent to which this business of suppressing negative data skews the scientific objective is evident. It’s evident to anybody. I’ve got an apple crop. Half of it’s rotten on the tree. I show you a cwt. of good apples. You think, based on that sample, that the whole lot’s good. You buy it all, and by the time it reaches you, the whole lot is rotten.

    Everybody knows this. The MHRA even has a means of tracking whether trials have been reported, or not. But they don’t bother to follow up. Apathy, incompetence, or corruption? You decide.

    Matt

  2. truthman30 Says:

    Apathy, incompetence, or corruption?

    Amd possibly a sprinkle of indifference , ignorance and arrogance too?…


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