GlaxoSmithKline – the game is up as Seroxat is proved to be no better than a sugar pill, but so much more dangerous

I’ve been an interested observer today – and what a holy shit-storm of a day.

It’s everywhere – the drugs don’t work – they just make you worse.

Bob Fiddaman has the very best round up of all the stories here… and doesn’t it just go on and on.

And all the while Glaxo squirms and spins:

GlaxoSmithKline, makers of Seroxat, said the authors of the study had “failed to acknowledge” the very positive benefits of SSRIs and their conclusions were “at odds with the very positive benefits seen in actual clinical practice.” A spokesperson added: “This one study should not be used to cause unnecessary alarm for patients.

BUT THE SPOKESPERSON HAS MISSED THE POINT – THIS IS NOT JUST ONE STUDY… IT’S LOTS OF THEM ANALYSED TOGETHER YOU IDIOT.

AND WHO IS TO SAY ANY POSITIVE EFFECT SEEN IN CLINICAL PRACTICE IS NOT MERELY A PLACEBO EFFECT?

Jeremy Laurance in the Independent sums it all up very well – The vested interests that conspire to bury bad news…“Publication bias” is not a phrase widely familiar to people outside the world of academic research. Yet it can explain how a drug launched as a safe and effective treatment can later turn out to be useless, or even deadly.Pharmaceutical companies invest millions of pounds in drug research and have a powerful commercial interest in publishing positive findings for the medicines they have spent years developing.

But they are equally keen to keep quiet about those trials which show no effect.

Medical journals comply in this process of self-censorship because, like the lay media, they are competing for readers and positive results – the more dramatic the better – attract more attention. The result is that over months and years, an impression is created that a drug is more effective, and has fewer side-effects, than is really the case.This is known as “publication bias”, the selection of only positive studies for publication. If all the studies conducted, positive and negative, were reviewed the overall impression might be very different.

Publication bias has been blamed for the debacle over the powerful painkiller Vioxx, dramatically withdrawn from the market in 2004, after it was suspected of causing heart attacks. The fatal side-effect had not been picked up despite years of research in thousands of patients. Now it is being blamed for the revelation that two decades after their launch, the new-generation anti-depressants, including Prozac and Seroxat, may be no better than placebos.

Data obtained from the Food and Drug Administration in the United States under freedom of information legislation showed that when all the trials, published and unpublished, submitted at the time the drugs were licensed were analysed, it showed no clinically significant effect. The finding makes the review of the present Nice guidelines on the treatment of depression “all the more urgent”, according to Tim Kendall, the head of group responsible for drawing them up.

The present guidelines, issued in 2004, recommend psychological treatments be offered as an alternative to drugs, especially in mild depression, a change from the original guidelines which recommended drugs as the first line of treatment. Revised guidelines are due at the end of the year.

Dr Kendall, a consultant psychiatrist in Sheffield, said: “The doubt the study raises is how much confidence we can have in our current data set, which is much bigger [than in the study] but may not be complete. The drug industry says they are being much more open but I am not convinced we are seeing the data we should see, and we are certainly not seeing what the licensing authorities are seeing.”

5 Responses to “GlaxoSmithKline – the game is up as Seroxat is proved to be no better than a sugar pill, but so much more dangerous”

  1. Matthew Holford Says:

    Sorry to go over old ground, but do you remember all the fun and games that I had with Dick Goldfinch? He told me that there was no definition of efficacy. He told me that it was not known how much more beneficial than placebo Seroxat was. He told me that it just was, and then he told me to “fuck off” (actually he told me that I was vexatious and that no further correspondence was being entered into with me on the subject of Seroxat, but the effect is much the same).

    Well, now, it seems that NICE has a definition of efficacy: 3 Hamilton points more effective than placebo (as such, SSRIs, at 1.8 points, are a big pile of kak). Also, it seems that NICE knew about this 1.8 points.

    Am I fucking missing something here? Why does the body that passes drugs for use on the NHS know about this stuff, when the body that licences drugs for use by hoi polloi seems to know absolutely FUCK ALL? I must be missing something, because that looks like one mega-sized cluster fuck, to me.

    Matt

  2. truthman30 Says:

    GSK denied there were any problem with Myodil too..
    Even though it was banned in many countries and peoples spines were crippled from it..

    http://www.thompsons.law.co.uk/Product-Liability/Myodil.htm

    Myodil

    What is Myodil?

    Myodil is a dye made from a mixture of isomers which was used for many years in hospitals and clinics.

    The dye was injected into the spines or spinal cords of people suffering from back pain to make x-rays clearer to read.

    In the 1950’s concerns over the safety of Myodil arose and the product was withdrawn from use in certain countries, including Sweden. It continued to be used in the United Kingdom until 1987.

    Eventually the dye was found to be toxic and if it was not removed completely after the x-rays were taken, it could cause arachnoiditis to develop, which is an excruciatingly painful condition.

    In 1995, over 400 people made compensation claims against the manufacturers of Myodil, GlaxoSmithKlein. The company paid out approximately £7m in damages but did not admit liability for the injuries.

    http://www.abc.net.au/pm/content/2005/s1404355.htm

    http://www.myodil.plus.com/

    http://www.parliament.nsw.gov.au/prod/parlment/hansart.nsf/V3Key/LC19940915023

    Seroxat has harmed tens of thousands of people wordwide..
    Myodil has harmed tens of thousands of people worldwide..
    The evidence for both causing harm is beyond argument..
    Avandia will be next..
    But GSK will deny that too..
    Even though Avandia FDA scientists estimate that Avandia has caused roughly 83000 heart attacks…

    http://www.expertclick.com/NewsReleaseWire/default.cfm?Action=ReleaseDetail&ID=20201

    GSK have more drugs in late stage clinical trials, and some will be coming on stream this year…

    One such drug has already caused a lot of controversy , it is GSK’s vaccine “Rotarix” ..

    http://www.kristiemcnealy.com/rotarix-rotavirus-vaccine-linked-to-pneumonia-deaths/

    Rotarix Rotavirus Vaccine Linked to Pneumonia Deaths

    US officials released a report on Friday which examined the findings of 11 trials of a new oral rotavirus vaccine from GlaxoSmithKline. The report stated that the vaccine was effective at preventing rotavirus infection. Unfortunately, it was also linked to a significant increase in pneumonia deaths in children, as well as an increase in convulsions and bronchitis

    http://news.in.msn.com/national/article.aspx?cp-documentid=1258741

    http://www.pharmatimes.com/WorldNews/article.aspx?id=12914

    http://www.kristiemcnealy.com/rotarix-rotavirus-vaccine-linked-to-pneumonia-deaths/

    There are many other reports of GSK drugs and products being defective and causing harm…

    http://www.whale.to/v/lyme45.html (Lymerix)

    http://www.whale.to/vaccine/urabe.html (Plucerix)

    http://www.whale.to/drugs/relenza.html (Relenza)

    Does GSK knowingly release toxic and defective drugs in a desperate and hurried attempt at competitiveness in an industry which is most fierce when it comes to market share?..

    Surely the pharmaceutical industry should hold the safety of its medications as the most important factor of the way is does business? After all, we are dealing with life and death, literally…

    Or does GSK know that to prove and individual death from ANY medication is one of the most difficult cases in law to prove?

    Even when a drug has known risks linking to the cause of death, finding a lawyer and proving it in court is a very different matter…

    Are the easiest people to prey on the sick the vulnerable, the ill and the dying?..

    With GSK, this seems to be the way it is…

  3. Lynn Says:

    We should challenge the CEO’s to take their own medicine, in public.

  4. Troy Says:

    Hi Seroxet Secrets:

    Great site! I’m working with James S. Gordon, MD to help him educate the public about natural approaches to treating depression instead of using SSRIs, which often don’t even work and have horrible side-effects (I know I’m preaching to the choir). As you may know, Dr. Gordon runs the non-profit Center for Mind-Body Medicine in DC and has been an integrative medicine pioneer for almost 40 years, teaching Self-Care techniques like mind-body health, physical exercise and proper eating to hundreds of thousands of people around the world to treat and prevent illness.

    He recently wrote a book, Unstuck, that discusses the horrors of prescription antidepressants and provides a comprehensive, natural approach that works. Someone in mainstream medicine is finally taking on the drug companies. It seems like a like of readers of your site would appreciate learning what else is out there besides prescription antidepressants to treat their depression. We’re following in Oprah and Eckhart Tolle’s footsteps and have created a free four part online web series called “A Natural Approach to Treating Depression,” starting on November 18th. It includes four video classes plus a bunch of free downloads, like a Workbook (PDF), an audio relaxation exercise (MP3), video demonstrating a relaxation exercise, and other materials – all for free. We just want to get the truth out about antidepressants just like you.

    Would you consider posting the information about this program on your site (and other blogs)? I’ve attached the press release and included the essentials below. Dr. Gordon is also available for interviews if you are interested. Thanks for your consideration. Don’t hesitate to email or call me with questions or comments. If you want to check out an overview of his recent book on the topic, here is a recent article: http://hubpages.com/hub/A-Natural-Program-for-Treating-Depression-Book-Review-of-Unstuck Thank you!

    All the best,

    Troy Centazzo

    Free Online Learning Event: “A Natural Approach to Treating Depression” with James S. Gordon, MD
    – Four Web Classes from November 18-24

    Lesson 1 – An Overview of Depression and How You Can Treat it Yourself with the Help of a Guide

    Premiere Date and Time: Tuesday, November 18th at 8:30 EST.
    Lesson 2 – Relaxation/Stress Management. Premiere Date and Time: Thursday, November 20th at 8:30 EST.

    Lesson 3 – Exercise and Movement Premiere Date and Time: Saturday, November 22nd at 6:30 EST. (note time change)

    Lesson 4 – Other Useful Techniques and Advice for Participants Premiere Date and Time: Monday, November 24th at 8:30 EST

    Other Resources Provided: The “Unstuck Pack”

    Before the series begins, participants can go to the series’ website and download the free Unstuck Pack, which includes:

    • The Unstuck Workbook & Journal to use with the course
    • An audio relaxation exercise for an MP3 player
    • A guide to relaxation and meditation to use with the exercise
    • A follow-along video, which visually demonstrates a relaxation exercise
    • An excerpt of the Introduction to “Unstuck: Your Guide to the Seven-Stage Journey Out of Depression”

    Sign up and additional information is at http://www.mblwellness.com/unstuck/

  5. Andrew Witty admits defeat on “expensive, high risk” depression drugs « seroxat secrets… Says:

    […] maybe Seroxat didn’t actually work any better than a sugar pill… maybe the ‘chemical cure’ was a lie… maybe Glaxo had no idea how Seroxat […]


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