Seroxat/Paxil for Pre Menstrual Syndrome – no conflicts of interest…?

In my last post – link – I wondered if Dr Mikael Landen had any connections with GSK and who funded his research, as recent research he had done seemed to show that Seroxat/Paxil would be good for some people to take for a few days every month to ease Pre Menstrual Syndrome:

Doctors are testing women taking antidepressants at the first symptom of premenstrual irritability, a move critics worry could lead to even more prescribing of “psychotropic” drugs to women.

A small new study shows antidepressants work within hours to dampen premenstrual anger and irritability. It usually takes several weeks for the drugs to start working in depression, and months before a maximum effect is achieved.

But studies suggest a popular class of drugs called SRIs, or serotonin reuptake inhibitors, work more rapidly to reduce symptoms such as irritability and anger.

Now this seemed strange to me and others as in our experience Seroxat/Paxil CAUSES anger and irritability, especially when you withdraw from the drug or alter the dosage you take. It would therefore seem a stupid thing to do to take 20mgs for 6 or seven days a month and then stop, only to repeat the process the next month.

Thanks to Bob Fiddaman, we now know who funded this ‘research’:

“The study was supported by grants from Novo Nordisk Sweden and GlaxoSmithKline. We thank study nurses Benita Gezelius and Carin Carlquist forskillful assistance. Dr Brian Hunter at Glaxo SmithKline gave valuable input on the study protocol. Niklas Morton and Gunnar Ekroth provided valuable statistical advice.”

Interestingly enough another study was being carried out into the same thing at the same time – and it was published at the same time. This study took place in Canada.

The detail can be found (once again) at Seroxat Sufferers:

This study was conducted by M Steiner, AV Ravindran, JM Lemelledo, D Carter, JO Huang, AM Anonychuk, and SD Simpson.

The declaration of interests [Financial Disclosure] shows what I believe to be a severe conflict of interests in this study.

First and foremost the study was funded by GlaxoSmithKline, Canada.

Dr. Steiner has served as a consultant to Eli Lilly, Pfizer, GlaxoSmithKline, Lundbeck, Novartis, Wyeth, Ortho- McNeil, AstraZeneca, and Azevan; has served on the speakers bureaus of AstraZeneca, Eli Lilly, Pfizer, GlaxoSmithKline, and Wyeth; has served on the advisory boards of Eli Lilly, Pfizer, GlaxoSmithKline, Lundbeck, Ortho-McNeil, Wyeth, Sherring, Ferring, and Azevan; and has received grant/research support from Wyeth, Pfizer, AllerGen, AstraZeneca, Canadian Institutes of Health Research, Society for Women’s Health Research, Ontario Mental Health Foundation, and Physicians Services Inc. Foundation.

Dr. Ravindran has received grant/research support from, served as a consultant for and on the advisory boards of, and participated in continuing medical education programs sponsored by AstraZeneca, Cephalon, Eli Lilly, GlaxoSmithKline, Janssen-Ortho, Pfizer, Roche, Servier, and Wyeth.

Dr. LeMelledo has received honorarium and performed clinical trials for Roche, AstraZeneca, GlaxoSmithKline, Pfizer, and Merck and has received funding from Canadian Institutes of Health Research, Canadian Psychiatric Research Foundation, and University of Alberta.

Dr. Carter has received grant/research support from Wyeth.

Mss. Huang and Anonychuk and Dr. Simpson are employees of GlaxoSmithKline, Canada.

Honestly, from my own experience (and the experience of tens of thousands of others, the ABSOLUTE LAST THING you would ever want to do is to take Seroxat/Paxil for 6 days then stop, then do the same again each month.

How can these studies have come to the conclusions they did?

We need to know more.

One Response to “Seroxat/Paxil for Pre Menstrual Syndrome – no conflicts of interest…?”

  1. BOB FIDDAMAN Says:

    How can these studies have come to the conclusions they did?

    Um… take a wild guess!

    Fid


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