Seroxat Interferes With Breast Cancer Drug – “patients more likely to die”

This news is all over the internet – yet another black mark against Seroxat… how did this drug ever get licensed in the first place?

I wonder how much more bad news Glaxo knows about Seroxat but has kept hidden all these years? After all, the company made huge profits from Seroxat and that was what was important – not patient safety.

This from Phil Dawdy at Furious Seasons (who sums things up very well):

This alarming bit of news hit yesterday:

“Women who took GlaxoSmithKline’s Paxil while taking tamoxifen at the same time were more likely to die of their breast cancer, the researchers found. The longer the overlap between Paxil and tamoxifen, the more likely the patients were to die, they reported in the British Medical Journal. “It is likely because Paxil, sold generically as paroxetine, interferes with the compound the body uses to process tamoxifen, the researchers said.”

A separate study last year reached a similar conclusion about SSRIs as a class.

At this point, you’ve got to wonder if there’s nothing Paxil cannot do. It increases suicidality, is linked to some birth defects, has all kinds of dependence and withdrawal problems and even damages male sperm. Awesome little pill, Glaxo.

If you’re in the unfortunate situation of taking both Seroxat and Tamoxifen, I would suggest you don’t stop the Seroxat abruptly – see your Doctor and work out a plan for a controlled withdrawal from the drug.


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